By L. Kulak. Marian College.

Respiratory depression may be due either wholly or in part to other drugs used during the conduct of general anesthesia such as narcotics buy 400mg trental with mastercard, thiobarbiturates and other central nervous system depressants buy discount trental 400 mg online. Under such circumstances the primary treatment is maintenance of a patent airway and manual or mechanical ventilation until complete recovery of normal respiration is assured generic 400mg trental otc. Regonol (pyridostigmine bromide) injection, neostigmine, or edrophonium, in conjunction with atropine or glycopyrrolate will usually antagonize the skeletal muscle relaxant action of Norcuron. Satisfactory reversal can be judged by adequacy of skeletal muscle tone and by adequacy of respiration. A peripheral nerve stimulator may also be used to monitor restoration of twitch height. Failure of prompt reversal (within 30 minutes) may occur in the presence of extreme debilitation, carcinomatosis, and with concomitant use of certain broad spectrum antibiotics, or anesthetic agents and other drugs which enhance neuromuscular blockade or cause respiratory depression of their own. Under such circumstances the management is the same as that of prolonged neuromuscular blockade. Ventilation must be supported by artificial means until the patient has resumed control of his respiration. Prior to the use of reversal agents, reference should be made to the specific package insert of the reversal agent. Dosage and Administration: Norcuron (vecuronium bromide) for injection is for intravenous use only. To obtain maximum clinical benefits of Norcuron and to minimize the possibility of overdosage, the monitoring of muscle twitch response to peripheral nerve stimulation is advised. This dose can be expected to produce good or excellent non‐emergency intubation conditions in 2. Under balanced anesthesia, clinically required neuromuscular blockade lasts approximately 25‐30 minutes, with recovery to 25% of control achieved approximately 25 to 40 minutes after injection and recovery to 95% of control achieved approximately 45‐65 minutes after injection. In the presence of potent inhalation anesthetics, the neuromuscular blocking effect of Norcuron is enhanced.

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